{"id":6576,"date":"2019-10-18T16:16:00","date_gmt":"2019-10-18T16:16:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=6576"},"modified":"2022-04-20T11:38:47","modified_gmt":"2022-04-20T11:38:47","slug":"granulocyte-and-monocyte-adsorption-apheresis-for-psoriatic-arthritis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorption-apheresis-for-psoriatic-arthritis\/","title":{"rendered":"Granulocyte and monocyte adsorption apheresis for psoriatic arthritis"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Takuro Kanekura<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>poster at ISFA 2019 pag 58<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Adsorptive granulocyte and monocyte apheresis (GMA) with the Adacolumn is an extracorporeal treatment, which uses cellulose acetate (CA) beads as adsorptive leucocytapheresis carriers designed to remove elevated and potentially activated myeloid lineage leucocytes. Case series studies on the clinical effectiveness of GMA on skin diseases and associated arthropathy attributable to activated myeloid lineage leucocytes returned remarkable outcome without any serious adverse events. Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy associated with psoriasis. PsA is an intractable immune disorder and refractory to pharmacological intervention. Efficacy of selective depletion of myeloid lineage leucocytes in patients with PsA was assessed.in a multicenter setting. A total of 20 patients with moderate to severe PsA refractory to conventional and biological disease-modifying antirheumatic drugs were enrolled. Each patient received 5 sessions of GMA once a week. The primary efficacy outcome was 20% or more decrease in the American College of Rheumatology score 20 (ACR20). Partial responders received an additional 5 GMA sessions. Of 20 patients, 2 did not complete the study, 9 responded to 5 GMA sessions and 9 received 10 sessions. At the first evaluation 2 weeks after the last GMA session, 13 of the 20 (65.0%) patients achieved ACR20. ACR20 was maintained in 7 of 10 (70%) and 5 of 10 (50%) patients at the follow-up evaluation points 8 and 20 weeks after the last GMA session, respectively. GMA was well tolerated without any safety concern. This multicenter study  demonstrated that GMA was effective with good safety profile in patients with PsA refractory to pharmacologicals, We present the results of this study and mode of action of GMA.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>h<a href=\"\/\/www.atalacia.com\/isfa\/data\/abstract.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">ttp:\/\/www.atalacia.com\/isfa\/data\/abstract.pdf<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Takuro Kanekura poster at ISFA 2019 pag 58 Adsorptive granulocyte and monocyte apheresis (GMA) with the Adacolumn is an extracorporeal treatment, which uses cellulose acetate (CA) beads as adsorptive leucocytapheresis carriers designed to remove elevated and potentially activated myeloid lineage leucocytes. Case series studies on the clinical effectiveness of GMA on skin diseases and associated [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[480,446,424,181,100,80,53,156,271],"class_list":["post-6576","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-acr20","scientific_tags-effectiveness","scientific_tags-gma","scientific_tags-gmas-responders","scientific_tags-multicenter","scientific_tags-psoriatic-arthritis","scientific_tags-refractory-patients","scientific_tags-safety","scientific_tags-study"],"acf":{"sc_authors":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Granulocyte and monocyte adsorption apheresis for psoriatic arthritis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorption-apheresis-for-psoriatic-arthritis\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyte and monocyte adsorption apheresis for psoriatic arthritis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Takuro Kanekura poster at ISFA 2019 pag 58 Adsorptive granulocyte and monocyte apheresis (GMA) with the Adacolumn is an extracorporeal treatment, which uses cellulose acetate (CA) beads as adsorptive leucocytapheresis carriers designed to remove elevated and potentially activated myeloid lineage leucocytes. 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