{"id":5832,"date":"2004-06-25T10:32:00","date_gmt":"2004-06-25T10:32:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=5832"},"modified":"2022-01-25T15:04:29","modified_gmt":"2022-01-25T15:04:29","slug":"adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and\/","title":{"rendered":"Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: Evidence for the involvement of plasma IgG, complement C3 and \u03b22 integrin"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00011-004-1253-5#auth-Y_-Takeda\">Y. Takeda<\/a>,\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00011-004-1253-5#auth-N_-Shiobara\">N. Shiobara<\/a>,\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00011-004-1253-5#auth-A__R_-Saniabadi\">A. R. Saniabadi<\/a>,\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00011-004-1253-5#auth-M_-Adachi\">M. Adachi<\/a>\u00a0&amp;\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00011-004-1253-5#auth-K_-Hiraishi\">K. Hiraishi<\/a>, <a href=\"https:\/\/link.springer.com\/journal\/11\"><em>Inflammation Research<\/em><\/a>\u00a0<strong>volume\u00a053<\/strong>,\u00a0pages 277\u2013283 (2004)<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><em>Objective:<\/em> Evolving evidence of anti-inflammatory effects is observed in patients with rheumatoid arthritis or ulcerative colitis following periodic adsorptive granulocyte and monocyte (GM) apheresis with a column containing cellulose acetate (CA) beads as apheresis carriers. This study was undertaken to obtain insights into mechanisms of anti-inflammatory actions of adsorptive GM apheresis with CA beads. <em>Methods:<\/em> In a series of in-vitro experiments, we investigated the effects of plasma proteins and the leucocytes \u03b22 integrin (CD18) on granulocyte adsorption to CA beads. <em>Results:<\/em> Granulocyte adsorption to CA beads required plasma IgG, the complement C3 and was inhibited by an antibody to leucocytes CD18. Further, hepatocyte growth factor (HGF) and interleukin-1 receptor antagonist (IL-1ra) which have strong anti-inflammatory actions were released by granulocytes that adhered to CA beads. <em>Conclusions:<\/em> Plasma IgG, C3 derived complement activation fragments and leucocytes CD18 are involved in granulocyte adhesion to CA beads and hence the release of HGF and IL-1ra.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00011-004-1253-5\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/link.springer.com\/article\/10.1007\/s00011-004-1253-5<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Y. Takeda,\u00a0N. Shiobara,\u00a0A. R. Saniabadi,\u00a0M. Adachi\u00a0&amp;\u00a0K. Hiraishi, Inflammation Research\u00a0volume\u00a053,\u00a0pages 277\u2013283 (2004) Objective: Evolving evidence of anti-inflammatory effects is observed in patients with rheumatoid arthritis or ulcerative colitis following periodic adsorptive granulocyte and monocyte (GM) apheresis with a column containing cellulose acetate (CA) beads as apheresis carriers. This study was undertaken to obtain insights into mechanisms [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[508,507,119,424,105,474,506,473,107],"class_list":["post-5832","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-b2-integrin","scientific_tags-c3","scientific_tags-complement","scientific_tags-gma","scientific_tags-granulocyte","scientific_tags-hgf","scientific_tags-igg","scientific_tags-il-1ra","scientific_tags-monocyte"],"acf":{"sc_authors":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: Evidence for the involvement of plasma IgG, complement C3 and \u03b22 integrin - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: Evidence for the involvement of plasma IgG, complement C3 and \u03b22 integrin - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Y. Takeda,\u00a0N. Shiobara,\u00a0A. R. Saniabadi,\u00a0M. Adachi\u00a0&amp;\u00a0K. Hiraishi, Inflammation Research\u00a0volume\u00a053,\u00a0pages 277\u2013283 (2004) Objective: Evolving evidence of anti-inflammatory effects is observed in patients with rheumatoid arthritis or ulcerative colitis following periodic adsorptive granulocyte and monocyte (GM) apheresis with a column containing cellulose acetate (CA) beads as apheresis carriers. This study was undertaken to obtain insights into mechanisms [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-25T15:04:29+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"1\u00a0Minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and\/\",\"name\":\"Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: Evidence for the involvement of plasma IgG, complement C3 and \u03b22 integrin - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2004-06-25T10:32:00+00:00\",\"dateModified\":\"2022-01-25T15:04:29+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: Evidence for the involvement of plasma IgG, complement C3 and \u03b22 integrin - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and\/","og_locale":"de_DE","og_type":"article","og_title":"Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: Evidence for the involvement of plasma IgG, complement C3 and \u03b22 integrin - Adacyte","og_description":"Y. Takeda,\u00a0N. Shiobara,\u00a0A. R. Saniabadi,\u00a0M. Adachi\u00a0&amp;\u00a0K. Hiraishi, Inflammation Research\u00a0volume\u00a053,\u00a0pages 277\u2013283 (2004) Objective: Evolving evidence of anti-inflammatory effects is observed in patients with rheumatoid arthritis or ulcerative colitis following periodic adsorptive granulocyte and monocyte (GM) apheresis with a column containing cellulose acetate (CA) beads as apheresis carriers. This study was undertaken to obtain insights into mechanisms [&hellip;]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and\/","og_site_name":"Adacyte","article_modified_time":"2022-01-25T15:04:29+00:00","twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"1\u00a0Minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and\/","name":"Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: Evidence for the involvement of plasma IgG, complement C3 and \u03b22 integrin - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2004-06-25T10:32:00+00:00","dateModified":"2022-01-25T15:04:29+00:00","inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/adhesion-dependent-release-of-hepatocyte-growth-factor-and-interleukin-1-receptor-antagonist-from-human-blood-granulocytes-and-monocytes-evidence-for-the-involvement-of-plasma-igg-complement-c3-and\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner\/5832","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/media?parent=5832"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific_tags?post=5832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}