{"id":5568,"date":"2014-07-01T08:25:00","date_gmt":"2014-07-01T08:25:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=5568"},"modified":"2021-07-12T07:49:22","modified_gmt":"2021-07-12T07:49:22","slug":"effects-of-preoperative-leukocytapheresis-on-inflammatory-cytokines-following-surgery-for-ulcerative-colitis-a-prospective-randomized-study","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/effects-of-preoperative-leukocytapheresis-on-inflammatory-cytokines-following-surgery-for-ulcerative-colitis-a-prospective-randomized-study\/","title":{"rendered":"Effects of Preoperative Leukocytapheresis on Inflammatory Cytokines Following Surgery for Ulcerative Colitis: A Prospective Randomized Study"},"content":{"rendered":"
\n

Takuya Bamba<\/a> 1<\/a><\/sup>, Takayuki Yamamoto<\/a>, Satoru Umegae<\/a>, Koichi Matsumoto<\/a>, J Clin Apher. 2014 Apr;29(2):107-12.<\/p>\n<\/div>\n\n

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Targeted extracorporeal granulocyte and monocyte apheresis (GMA) has produced clinical efficacy together with down modulation of specific inflammatory cytokines in patients with ulcerative colitis (UC). This study was to investigate if preoperative GMA produces immunological effect on dysregulated immune activity after restorative proctocolectomy (RPC) in patients with UC. Forty patients requiring RPC were included. Twenty randomly selected patients received five GMA sessions with the Adacolumn over two consecutive weeks before RPC (GMA group). RPC was performed within 2 weeks following the last GMA session. The other 20 patients did not receive GMA before RPC (non-GMA group). Blood samples were obtained immediately before surgery, at 1 h after surgery, and on postoperative Days 1, 3, and 7 from all patients. Abdominal exudate was obtained from the drainage tube at 1 h after surgery, and on postoperative Days 1, 3, and 7. Concentrations of interleukin (IL)-1\u03b2, IL-6, and tumor necrosis factor (TNF)-\u03b1 in plasma and peritoneal fluid from a drainage tube were measured by enzyme linked immunosorbent assay. Between the two groups, patients were matched with respect to age, sex, UC duration, severity, extent and the dose of prednisolone at surgery. IL-1\u03b2, IL-6, and TNF-\u03b1 levels in plasma and peritoneal fluid were not significantly different between the two groups during the entire study period. Based on the assays of IL-1\u03b2, IL-6, and TNF-\u03b1 levels in the plasma and the peritoneal fluid, this study did not find any effect on these inflammatory cytokines by preoperative GMA in patients with UC who underwent RPC.<\/p>\n<\/div>\n\n

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https:\/\/pubmed.ncbi.nlm.nih.gov\/24000140\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Takuya Bamba 1, Takayuki Yamamoto, Satoru Umegae, Koichi Matsumoto, J Clin Apher. 2014 Apr;29(2):107-12. Targeted extracorporeal granulocyte and monocyte apheresis (GMA) has produced clinical efficacy together with down modulation of specific inflammatory cytokines in patients with ulcerative colitis (UC). This study was to investigate if preoperative GMA produces immunological effect on dysregulated immune activity after restorative proctocolectomy (RPC) in […]<\/p>\n","protected":false},"template":"","scientific_tags":[79,377,378,306],"class_list":["post-5568","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-cytokines","scientific_tags-restorative-proctocolectomy","scientific_tags-septic","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":""},"yoast_head":"\nEffects of Preoperative Leukocytapheresis on Inflammatory Cytokines Following Surgery for Ulcerative Colitis: A Prospective Randomized Study - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effects-of-preoperative-leukocytapheresis-on-inflammatory-cytokines-following-surgery-for-ulcerative-colitis-a-prospective-randomized-study\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effects of Preoperative Leukocytapheresis on Inflammatory Cytokines Following Surgery for Ulcerative Colitis: A Prospective Randomized Study - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Takuya Bamba 1, Takayuki Yamamoto, Satoru Umegae, Koichi Matsumoto, J Clin Apher. 2014 Apr;29(2):107-12. Targeted extracorporeal granulocyte and monocyte apheresis (GMA) has produced clinical efficacy together with down modulation of specific inflammatory cytokines in patients with ulcerative colitis (UC). This study was to investigate if preoperative GMA produces immunological effect on dysregulated immune activity after restorative proctocolectomy (RPC) in […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effects-of-preoperative-leukocytapheresis-on-inflammatory-cytokines-following-surgery-for-ulcerative-colitis-a-prospective-randomized-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2021-07-12T07:49:22+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effects-of-preoperative-leukocytapheresis-on-inflammatory-cytokines-following-surgery-for-ulcerative-colitis-a-prospective-randomized-study\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effects-of-preoperative-leukocytapheresis-on-inflammatory-cytokines-following-surgery-for-ulcerative-colitis-a-prospective-randomized-study\/\",\"name\":\"Effects of Preoperative Leukocytapheresis on Inflammatory Cytokines Following Surgery for Ulcerative Colitis: A Prospective Randomized Study - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2014-07-01T08:25:00+00:00\",\"dateModified\":\"2021-07-12T07:49:22+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effects-of-preoperative-leukocytapheresis-on-inflammatory-cytokines-following-surgery-for-ulcerative-colitis-a-prospective-randomized-study\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Effects of Preoperative Leukocytapheresis on Inflammatory Cytokines Following Surgery for Ulcerative Colitis: A Prospective Randomized Study - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effects-of-preoperative-leukocytapheresis-on-inflammatory-cytokines-following-surgery-for-ulcerative-colitis-a-prospective-randomized-study\/","og_locale":"de_DE","og_type":"article","og_title":"Effects of Preoperative Leukocytapheresis on Inflammatory Cytokines Following Surgery for Ulcerative Colitis: A Prospective Randomized Study - Adacyte","og_description":"Takuya Bamba 1, Takayuki Yamamoto, Satoru Umegae, Koichi Matsumoto, J Clin Apher. 2014 Apr;29(2):107-12. 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