{"id":5474,"date":"2021-06-28T10:07:46","date_gmt":"2021-06-28T10:07:46","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=5474"},"modified":"2024-05-02T09:56:54","modified_gmt":"2024-05-02T07:56:54","slug":"granulocyte-and-monocyte-adsorptive-apheresis-induces-apoptosis-of-neutrophils-and-release-of-a-novel-chemoattractant-for-desensitization-of-interleukin-8-response","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorptive-apheresis-induces-apoptosis-of-neutrophils-and-release-of-a-novel-chemoattractant-for-desensitization-of-interleukin-8-response\/","title":{"rendered":"Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kashiwagi+N&amp;cauthor_id=33395614\">Nobuhito Kashiwagi<\/a><sup>&nbsp;<\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Saito+F&amp;cauthor_id=33395614\">Fumio Saito<\/a><sup>&nbsp;<\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Maegawa+H&amp;cauthor_id=33395614\">Hidetaka Maegawa<\/a><sup>&nbsp;<\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kaneda+K&amp;cauthor_id=33395614\">Kenta Kaneda<\/a>, Cytokine&nbsp;2021 Mar;139:155410.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Objective:\u00a0<\/strong>Apoptotic cells participate in maintenance of homeostasis of the adaptive immune system. Granulocyte\/monocyte adsorptive apheresis (GMA) performed with an Adacolumn has been shown to have clinical efficacy together with immunomodulatory effects for immune-mediated disorder cases, such as inflammatory bowel disease (IBD) or psoriatic arthritis. Although induction of apoptosis in neutrophils by GMA has been observed, the detailed mechanism remains unclear. <strong>Methods:\u00a0<\/strong>To focus on phagocytosis-induced cell death (PICD) that induces apoptotic neutrophils, a comparative study utilizing a GMA-carrier (leukocyte adsorbing carrier for Adacolumn) and yeast particles was performed with in vitro and in vivo examinations. <strong>Results:\u00a0<\/strong>L-selectin was significantly (P = 0.0133) shed, reactive oxygen species (ROS) production was promoted (P = 0.0019), and apoptosis induction was enhanced (P = 0.0087) by peripheral blood co-cultured with the GMA-carrier or yeast particles as compared to incubated blood alone. Furthermore, degranulation of myeloperoxidase, elastase, and lactoferrin was increased by both treatments, while the highest level of interleukin-1 receptor antagonist release was found with GMA-carrier treatment (P = 0.0087) as compared to the yeast particles. Plasma from blood treated with the GMA-carrier showed chemotactic activity, and suppressed neutrophil migration to IL-8 and LTB<sub>4<\/sub>. In vivo results demonstrated that neutrophil chemotaxis to IL-8 was desensitized (P = 0.0078) in rabbits following GMA apheresis, while CXCR1 and CXCR2 expressions in neutrophils were reduced by exposing peripheral blood to the GMA-carrier. <strong>Conclusions:<\/strong> GMA may regulate the immune system in patients with an immune-mediated disorder by inducing a biological response of neutrophils with a PICD-like reaction.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33395614\/\">ht<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33395614\/\" target=\"_blank\" rel=\"noreferrer noopener\">tps:\/\/pubmed.ncbi.nlm.nih.gov\/33395614\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Nobuhito Kashiwagi&nbsp;,&nbsp;Fumio Saito&nbsp;,&nbsp;Hidetaka Maegawa&nbsp;,&nbsp;Kenta Kaneda, Cytokine&nbsp;2021 Mar;139:155410. Objective:\u00a0Apoptotic cells participate in maintenance of homeostasis of the adaptive immune system. Granulocyte\/monocyte adsorptive apheresis (GMA) performed with an Adacolumn has been shown to have clinical efficacy together with immunomodulatory effects for immune-mediated disorder cases, such as inflammatory bowel disease (IBD) or psoriatic arthritis. Although induction of apoptosis [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[229,255,283,586,424,473,268,312,230,583,584,581,582,445],"class_list":["post-5474","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-apoptosis","scientific_tags-chemokines","scientific_tags-cx3cr1","scientific_tags-cxcr2","scientific_tags-gma","scientific_tags-il-1ra","scientific_tags-il-8","scientific_tags-immunology","scientific_tags-lecam-1l-selectin","scientific_tags-lf","scientific_tags-ltb4","scientific_tags-mpo","scientific_tags-ne","scientific_tags-neutrophil"],"acf":{"sc_authors":"<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33395614\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33395614\/<\/a>"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorptive-apheresis-induces-apoptosis-of-neutrophils-and-release-of-a-novel-chemoattractant-for-desensitization-of-interleukin-8-response\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Nobuhito Kashiwagi&nbsp;,&nbsp;Fumio Saito&nbsp;,&nbsp;Hidetaka Maegawa&nbsp;,&nbsp;Kenta Kaneda, Cytokine&nbsp;2021 Mar;139:155410. Objective:\u00a0Apoptotic cells participate in maintenance of homeostasis of the adaptive immune system. Granulocyte\/monocyte adsorptive apheresis (GMA) performed with an Adacolumn has been shown to have clinical efficacy together with immunomodulatory effects for immune-mediated disorder cases, such as inflammatory bowel disease (IBD) or psoriatic arthritis. Although induction of apoptosis [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorptive-apheresis-induces-apoptosis-of-neutrophils-and-release-of-a-novel-chemoattractant-for-desensitization-of-interleukin-8-response\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-02T07:56:54+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorptive-apheresis-induces-apoptosis-of-neutrophils-and-release-of-a-novel-chemoattractant-for-desensitization-of-interleukin-8-response\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorptive-apheresis-induces-apoptosis-of-neutrophils-and-release-of-a-novel-chemoattractant-for-desensitization-of-interleukin-8-response\/\",\"name\":\"Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2021-06-28T10:07:46+00:00\",\"dateModified\":\"2024-05-02T07:56:54+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorptive-apheresis-induces-apoptosis-of-neutrophils-and-release-of-a-novel-chemoattractant-for-desensitization-of-interleukin-8-response\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-and-monocyte-adsorptive-apheresis-induces-apoptosis-of-neutrophils-and-release-of-a-novel-chemoattractant-for-desensitization-of-interleukin-8-response\/","og_locale":"de_DE","og_type":"article","og_title":"Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response - Adacyte","og_description":"Nobuhito Kashiwagi&nbsp;,&nbsp;Fumio Saito&nbsp;,&nbsp;Hidetaka Maegawa&nbsp;,&nbsp;Kenta Kaneda, Cytokine&nbsp;2021 Mar;139:155410. 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