{"id":11085,"date":"2023-11-21T17:13:00","date_gmt":"2023-11-21T16:13:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=11085"},"modified":"2025-08-08T17:17:12","modified_gmt":"2025-08-08T15:17:12","slug":"a-retrospective-study-to-investigate-the-efficacy-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-primary-sclerosing-cholangitis-with-ulcerative-colitis-3","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/a-retrospective-study-to-investigate-the-efficacy-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-primary-sclerosing-cholangitis-with-ulcerative-colitis-3\/","title":{"rendered":"A retrospective study to investigate the efficacy and safety of granulocyte and monocyte adsorptive apheresis in patients with primary sclerosing cholangitis with ulcerative colitis"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ito+A&amp;cauthor_id=37990778\">Ayumi Ito<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37990778\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Murasugi+S&amp;cauthor_id=37990778\">Shun Murasugi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37990778\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Yonezawa+M&amp;cauthor_id=37990778\">Maria Yonezawa<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37990778\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Omori+T&amp;cauthor_id=37990778\">Teppei Omori<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37990778\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Nakamura+S&amp;cauthor_id=37990778\">Shinichi Nakamura<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37990778\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Tokushige+K&amp;cauthor_id=37990778\">Katsutoshi Tokushige<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37990778\/#full-view-affiliation-1\">1<\/a><\/sup><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>J Clin Apher.\u00a02024 Feb;39(1):e22099.\u00a0doi: 10.1002\/jca.22099.\u00a0Epub 2023 Nov 21.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong class=\"sub-title\" style=\"color: rgb(33, 33, 33); font-family: BlinkMacSystemFont, -apple-system, &quot;Segoe UI&quot;, Roboto, Oxygen, Ubuntu, Cantarell, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, sans-serif; font-size: 16px; white-space-collapse: collapse; box-sizing: inherit;\">Background and aims:\u00a0<\/strong><span style=\"color: rgb(33, 33, 33); font-family: BlinkMacSystemFont, -apple-system, &quot;Segoe UI&quot;, Roboto, Oxygen, Ubuntu, Cantarell, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, sans-serif; font-size: 16px; white-space-collapse: collapse;\">Primary sclerosing cholangitis has a poor prognosis and can be accompanied by ulcerative colitis. Infection control is essential, so immunosuppressive drugs should ideally be preferably. Granulocyte and monocyte adsorptive apheresis does not suppress the immune system and is used to treat ulcerative colitis. Therefore, this study investigated the efficacy and safety of granulocyte and monocyte adsorptive apheresis in patients with primary sclerosing cholangitis and ulcerative colitis.<\/span><p style=\"box-sizing: inherit; line-height: 1.5; margin: 1.2rem 0px; color: rgb(33, 33, 33); font-family: BlinkMacSystemFont, -apple-system, &quot;Segoe UI&quot;, Roboto, Oxygen, Ubuntu, Cantarell, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, sans-serif; font-size: 16px; white-space-collapse: collapse;\"><strong class=\"sub-title\" style=\"box-sizing: inherit;\">Methods:\u00a0<\/strong>We retrospectively evaluated data from patients with primary sclerosing cholangitis with ulcerative colitis who visited our hospital from April 2000 to December 2022 and underwent granulocyte and monocyte adsorptive apheresis (n = 10, number of treatment cycles = 15). Study endpoints were remission induction rate and safety, assessed as changes in liver functions and adverse events.\u00a0<strong class=\"sub-title\" style=\"box-sizing: inherit;\">Results:\u00a0<\/strong>Seven of the 10 patients were male. The median (min-max) age was 23 (18-77) years. The most common disease type was right-dominant pancolitis. Remission occurred after 86.6% of cycles (13\/15). Serum alkaline phosphatase and Aspartate transaminase were significantly lower after treatment (P = .0124, P = .002), and no negative effects on liver function were seen. The only adverse events were headache (n = 1) and decreased blood pressure (n = 1).<strong class=\"sub-title\" style=\"box-sizing: inherit;\">Conclusions:\u00a0<\/strong>Granulocyte and monocyte adsorptive apheresis has high efficacy for intestinal lesions and improves alkaline phosphatase and aspartate transaminase levels (high levels are a poor prognosis factor). It appears to be a treatment option in patients with primary sclerosing cholangitis associated with ulcerative colitis.<\/p><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Ayumi Ito\u00a01,\u00a0Shun Murasugi\u00a01,\u00a0Maria Yonezawa\u00a01,\u00a0Teppei Omori\u00a01,\u00a0Shinichi Nakamura\u00a01,\u00a0Katsutoshi Tokushige\u00a01 J Clin Apher.\u00a02024 Feb;39(1):e22099.\u00a0doi: 10.1002\/jca.22099.\u00a0Epub 2023 Nov 21. Background and aims:\u00a0Primary sclerosing cholangitis has a poor prognosis and can be accompanied by ulcerative colitis. Infection control is essential, so immunosuppressive drugs should ideally be preferably. Granulocyte and monocyte adsorptive apheresis does not suppress the immune system and is [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147,157,424,333,48,156,271,918,306],"class_list":["post-11085","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-efficacy","scientific_tags-gma","scientific_tags-primary-sclerosing-cholangitis","scientific_tags-retrospective","scientific_tags-safety","scientific_tags-study","scientific_tags-transaminases","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":"<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37990778\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37990778\/<\/a>\r\n\r\n<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/jca.22099\">A retrospective study to investigate the efficacy and safety of granulocyte and monocyte adsorptive apheresis in patients with primary sclerosing cholangitis with ulcerative colitis - Ito - 2024 - Journal of Clinical Apheresis - Wiley Online Library<\/a>"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A retrospective study to investigate the efficacy and safety of granulocyte and monocyte adsorptive apheresis in patients with primary sclerosing cholangitis with ulcerative colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-study-to-investigate-the-efficacy-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-primary-sclerosing-cholangitis-with-ulcerative-colitis-3\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A retrospective study to investigate the efficacy and safety of granulocyte and monocyte adsorptive apheresis in patients with primary sclerosing cholangitis with ulcerative colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Ayumi Ito\u00a01,\u00a0Shun Murasugi\u00a01,\u00a0Maria Yonezawa\u00a01,\u00a0Teppei Omori\u00a01,\u00a0Shinichi Nakamura\u00a01,\u00a0Katsutoshi Tokushige\u00a01 J Clin Apher.\u00a02024 Feb;39(1):e22099.\u00a0doi: 10.1002\/jca.22099.\u00a0Epub 2023 Nov 21. Background and aims:\u00a0Primary sclerosing cholangitis has a poor prognosis and can be accompanied by ulcerative colitis. Infection control is essential, so immunosuppressive drugs should ideally be preferably. Granulocyte and monocyte adsorptive apheresis does not suppress the immune system and is [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-study-to-investigate-the-efficacy-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-primary-sclerosing-cholangitis-with-ulcerative-colitis-3\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-08T15:17:12+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-study-to-investigate-the-efficacy-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-primary-sclerosing-cholangitis-with-ulcerative-colitis-3\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-study-to-investigate-the-efficacy-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-primary-sclerosing-cholangitis-with-ulcerative-colitis-3\/\",\"name\":\"A retrospective study to investigate the efficacy and safety of granulocyte and monocyte adsorptive apheresis in patients with primary sclerosing cholangitis with ulcerative colitis - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2023-11-21T16:13:00+00:00\",\"dateModified\":\"2025-08-08T15:17:12+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-study-to-investigate-the-efficacy-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-primary-sclerosing-cholangitis-with-ulcerative-colitis-3\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A retrospective study to investigate the efficacy and safety of granulocyte and monocyte adsorptive apheresis in patients with primary sclerosing cholangitis with ulcerative colitis - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/a-retrospective-study-to-investigate-the-efficacy-and-safety-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-primary-sclerosing-cholangitis-with-ulcerative-colitis-3\/","og_locale":"de_DE","og_type":"article","og_title":"A retrospective study to investigate the efficacy and safety of granulocyte and monocyte adsorptive apheresis in patients with primary sclerosing cholangitis with ulcerative colitis - Adacyte","og_description":"Ayumi Ito\u00a01,\u00a0Shun Murasugi\u00a01,\u00a0Maria Yonezawa\u00a01,\u00a0Teppei Omori\u00a01,\u00a0Shinichi Nakamura\u00a01,\u00a0Katsutoshi Tokushige\u00a01 J Clin Apher.\u00a02024 Feb;39(1):e22099.\u00a0doi: 10.1002\/jca.22099.\u00a0Epub 2023 Nov 21. Background and aims:\u00a0Primary sclerosing cholangitis has a poor prognosis and can be accompanied by ulcerative colitis. Infection control is essential, so immunosuppressive drugs should ideally be preferably. 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