{"id":11081,"date":"2024-09-26T16:31:00","date_gmt":"2024-09-26T14:31:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=11081"},"modified":"2025-08-08T16:35:52","modified_gmt":"2025-08-08T14:35:52","slug":"dysregulated-myeloid-differentiation-in-colitis-is-induced-by-inflammatory-osteoclasts-in-a-tnf%ce%b1-dependent-manner","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/dysregulated-myeloid-differentiation-in-colitis-is-induced-by-inflammatory-osteoclasts-in-a-tnf%ce%b1-dependent-manner\/","title":{"rendered":"Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNF\u03b1-dependent manner"},"content":{"rendered":"
\n

Maria-Bernadette Madel<\/a>\u00a01<\/a><\/sup>,\u00a0Lidia Ib\u00e1\u00f1ez<\/a>\u00a01<\/a><\/sup>,\u00a0Thomas Ciucci<\/a>\u00a02<\/a><\/sup>,\u00a0Julia Halper<\/a>\u00a01<\/a><\/sup>,\u00a0Antoine Boutin<\/a>\u00a01<\/a><\/sup>,\u00a0Ghada Beldi<\/a>\u00a01<\/a><\/sup>,\u00a0Alice C Lavanant<\/a>\u00a03<\/a><\/sup>,\u00a0Henri-Jean Garchon<\/a>\u00a04<\/a><\/sup>,\u00a0Matthieu Rouleau<\/a>\u00a01<\/a><\/sup>,\u00a0Christopher G Mueller<\/a>\u00a03<\/a><\/sup>,\u00a0Laurent Peyrin-Biroulet<\/a>\u00a05<\/a><\/sup>,\u00a0David Moulin<\/a>\u00a06<\/a><\/sup>,\u00a0Claudine Blin-Wakkach<\/a>\u00a07<\/a><\/sup>,\u00a0Abdelilah Wakkach<\/a>\u00a08<\/a><\/sup><\/p>\n<\/div>\n\n

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Mucosal Immunol..\u00a02025 Feb;18(1):90-104.\u00a0doi: 10.1016\/j.mucimm.2024.09.005.\u00a0Epub 2024 Sep 26.<\/p>\n<\/div>\n\n

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Inflammatory bowel disease (IBD) is characterized by very severe intestinal inflammation associated with extra-intestinal manifestations. One of the most critical ones is bone destruction, which remains a major cause of morbidity and a risk factor for osteopenia and osteoporosis in IBD patients. In various mouse models of IBD, we and other have demonstrated concomitant bone loss due to a significant increase in osteoclast activity. Besides bone resorption, osteoclasts are known to control hematopoietic niches in vivo and modulate inflammatory responses in vitro, suggesting they may participate in chronic inflammation in vivo. Here, using different models of colitis, we showed that osteoclast inhibition significantly reduced disease severity and that induction of osteoclast differentiation by RANKL contributed to disease worsening. Our results demonstrate a direct link between osteoclast activity and myeloid cell accumulation in the intestine during colitis. RNAseq analysis of osteoclasts from colitic mice revealed overexpression of genes involved in the remodeling of hematopoietic stem cell niches. We also demonstrated that osteoclasts induced hematopoietic progenitor proliferation accompanied by a myeloid skewing in the early phases of colitis, which was confirmed in a model of RANKL-induced osteoclastogenesis. Mechanistically, inhibition of TNF-\u03b1 reduced the induction of myeloid skewing by OCL both in vitro and in vivo. Lastly, we observed that osteoclastic activity and the proportion of myeloid cells in the blood are positively correlated in patients with Crohn’s disease. Collectively, our results shed light on a new role of osteoclasts in colitis in vivo, demonstrating they exert their colitogenic activity through an early action on hematopoiesis, leading to an increase in myelopoiesis sustaining gut inflammation.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Maria-Bernadette Madel\u00a01,\u00a0Lidia Ib\u00e1\u00f1ez\u00a01,\u00a0Thomas Ciucci\u00a02,\u00a0Julia Halper\u00a01,\u00a0Antoine Boutin\u00a01,\u00a0Ghada Beldi\u00a01,\u00a0Alice C Lavanant\u00a03,\u00a0Henri-Jean Garchon\u00a04,\u00a0Matthieu Rouleau\u00a01,\u00a0Christopher G Mueller\u00a03,\u00a0Laurent Peyrin-Biroulet\u00a05,\u00a0David Moulin\u00a06,\u00a0Claudine Blin-Wakkach\u00a07,\u00a0Abdelilah Wakkach\u00a08 Mucosal Immunol..\u00a02025 Feb;18(1):90-104.\u00a0doi: 10.1016\/j.mucimm.2024.09.005.\u00a0Epub 2024 Sep 26. Inflammatory bowel disease (IBD) is characterized by very severe intestinal inflammation associated with extra-intestinal manifestations. One of the most critical ones is bone destruction, which remains a major cause of morbidity […]<\/p>\n","protected":false},"template":"","scientific_tags":[908,911,159,526,424,909,666,910,901,183,306],"class_list":["post-11081","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-bone-loss","scientific_tags-chronic-inflammation","scientific_tags-crohns-disease","scientific_tags-eim","scientific_tags-gma","scientific_tags-hematopoeiesis","scientific_tags-myeloid","scientific_tags-myelopoiesis","scientific_tags-osteoclasts","scientific_tags-tnf-","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"\nDysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNF\u03b1-dependent manner - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dysregulated-myeloid-differentiation-in-colitis-is-induced-by-inflammatory-osteoclasts-in-a-tnf\u03b1-dependent-manner\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNF\u03b1-dependent manner - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Maria-Bernadette Madel\u00a01,\u00a0Lidia Ib\u00e1\u00f1ez\u00a01,\u00a0Thomas Ciucci\u00a02,\u00a0Julia Halper\u00a01,\u00a0Antoine Boutin\u00a01,\u00a0Ghada Beldi\u00a01,\u00a0Alice C Lavanant\u00a03,\u00a0Henri-Jean Garchon\u00a04,\u00a0Matthieu Rouleau\u00a01,\u00a0Christopher G Mueller\u00a03,\u00a0Laurent Peyrin-Biroulet\u00a05,\u00a0David Moulin\u00a06,\u00a0Claudine Blin-Wakkach\u00a07,\u00a0Abdelilah Wakkach\u00a08 Mucosal Immunol..\u00a02025 Feb;18(1):90-104.\u00a0doi: 10.1016\/j.mucimm.2024.09.005.\u00a0Epub 2024 Sep 26. Inflammatory bowel disease (IBD) is characterized by very severe intestinal inflammation associated with extra-intestinal manifestations. One of the most critical ones is bone destruction, which remains a major cause of morbidity […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dysregulated-myeloid-differentiation-in-colitis-is-induced-by-inflammatory-osteoclasts-in-a-tnf\u03b1-dependent-manner\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-08T14:35:52+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dysregulated-myeloid-differentiation-in-colitis-is-induced-by-inflammatory-osteoclasts-in-a-tnf%ce%b1-dependent-manner\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dysregulated-myeloid-differentiation-in-colitis-is-induced-by-inflammatory-osteoclasts-in-a-tnf%ce%b1-dependent-manner\/\",\"name\":\"Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNF\u03b1-dependent manner - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-09-26T14:31:00+00:00\",\"dateModified\":\"2025-08-08T14:35:52+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dysregulated-myeloid-differentiation-in-colitis-is-induced-by-inflammatory-osteoclasts-in-a-tnf%ce%b1-dependent-manner\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNF\u03b1-dependent manner - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/dysregulated-myeloid-differentiation-in-colitis-is-induced-by-inflammatory-osteoclasts-in-a-tnf\u03b1-dependent-manner\/","og_locale":"de_DE","og_type":"article","og_title":"Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNF\u03b1-dependent manner - Adacyte","og_description":"Maria-Bernadette Madel\u00a01,\u00a0Lidia Ib\u00e1\u00f1ez\u00a01,\u00a0Thomas Ciucci\u00a02,\u00a0Julia Halper\u00a01,\u00a0Antoine Boutin\u00a01,\u00a0Ghada Beldi\u00a01,\u00a0Alice C Lavanant\u00a03,\u00a0Henri-Jean Garchon\u00a04,\u00a0Matthieu Rouleau\u00a01,\u00a0Christopher G Mueller\u00a03,\u00a0Laurent Peyrin-Biroulet\u00a05,\u00a0David Moulin\u00a06,\u00a0Claudine Blin-Wakkach\u00a07,\u00a0Abdelilah Wakkach\u00a08 Mucosal Immunol..\u00a02025 Feb;18(1):90-104.\u00a0doi: 10.1016\/j.mucimm.2024.09.005.\u00a0Epub 2024 Sep 26. 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