{"id":11074,"date":"2024-10-10T13:51:00","date_gmt":"2024-10-10T11:51:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=11074"},"modified":"2025-08-08T13:56:46","modified_gmt":"2025-08-08T11:56:46","slug":"asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis\/","title":{"rendered":"Asia-Pacific consensus recommendations on the management of generalized pustular psoriasis"},"content":{"rendered":"
\n

Siew Eng Choon<\/a>\u00a01<\/a><\/sup>,\u00a0Peter Anthony Foley<\/a>\u00a02<\/a>\u00a03<\/a><\/sup>,\u00a0Pravit Asawanonda<\/a>\u00a04<\/a><\/sup>,\u00a0Hideki Fujita<\/a>\u00a05<\/a><\/sup>,\u00a0Seong-Jin Jo<\/a>\u00a06<\/a><\/sup>,\u00a0Yu-Ling Shi<\/a>\u00a07<\/a>\u00a08<\/a><\/sup>,\u00a0Colin Theng<\/a>\u00a09<\/a><\/sup>,\u00a0Azura Mohd Affandi<\/a>\u00a010<\/a><\/sup>,\u00a0Chul Hwan Bang<\/a>\u00a011<\/a><\/sup>,\u00a0Maria Lorna Frez<\/a>\u00a012<\/a><\/sup>,\u00a0Huang Yu Huei<\/a>\u00a013<\/a>\u00a014<\/a><\/sup>,\u00a0Doanh Le Huu<\/a>\u00a015<\/a><\/sup>,\u00a0Tae-Gyun Kim<\/a>\u00a016<\/a><\/sup>,\u00a0Akimichi Morita<\/a>\u00a017<\/a><\/sup>,\u00a0Hazel H Oon<\/a>\u00a018<\/a>\u00a019<\/a><\/sup>,\u00a0Pablo Fern\u00e1ndez-Pe\u00f1as<\/a>\u00a020<\/a>\u00a021<\/a><\/sup>,\u00a0Natta Rajatanavin<\/a>\u00a022<\/a><\/sup>,\u00a0Suganthy Robinson<\/a>\u00a010<\/a><\/sup>,\u00a0Latha Selvarajah<\/a>\u00a023<\/a><\/sup>,\u00a0Tsen-Fang Tsai<\/a>\u00a024<\/a><\/sup><\/p>\n<\/div>\n\n

\n

J Dermatol.\u00a02024 Dec;51(12):1579-1595.\u00a0doi: 10.1111\/1346-8138.17471.\u00a0Epub 2024 Oct 10.<\/p>\n<\/div>\n\n

\n

Generalized pustular psoriasis (GPP) is a rare, chronic, heterogeneous, and potentially life-threatening disease characterized by primary, sterile, and macroscopically visible pustules with or without systemic symptoms. There are ethnic differences in the genetic mutations associated with GPP that might affect the clinical manifestations and treatment responses. Currently, there is limited evidence from the patient population in the Asia-Pacific (APAC) region, resulting in a general paucity of information on the effective management of patients with GPP in this region. This modified Delphi panel study aimed to identify current evidence and gain advanced insights to facilitate the development of a regionally tailored APAC consensus on the management of GPP. A systematic literature review (SLR) was conducted to identify published literature and develop consensus statements on (i) definition and clinical course, (ii) diagnosis of GPP, (iii) treatment outcomes, goals, and monitoring measures, and (iv) optimal management strategies and clinical practices. Statements were rated by a panel of dermatologists in two rounds, with the threshold for consensus at \u226580% agreement. Twenty experts from the APAC region reached consensus on 106 statements that were developed based on the SLR and experts‘ collective expertise. The experts agreed that GPP is a rare, severe, and potentially life-threatening condition that is distinct from plaque psoriasis. This consensus emphasized the importance of a tailored treatment strategy taking into account the GPP flare severity and each patient’s unique clinical circumstances. The experts reached consensus on the severity classification of GPP flares and recommended first-line and maintenance treatment options for adult GPP, childhood GPP, and GPP in pregnancy. These consensus outcomes have been synthesized into treatment algorithms to guide dermatologists in the APAC region in their clinical decision-making processes.<\/p>\n<\/div>\n\n

\n

Non-pharmacological treatments, such as GMA and IVIG, can be considered based on their availability in individual countries<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Siew Eng Choon\u00a01,\u00a0Peter Anthony Foley\u00a02\u00a03,\u00a0Pravit Asawanonda\u00a04,\u00a0Hideki Fujita\u00a05,\u00a0Seong-Jin Jo\u00a06,\u00a0Yu-Ling Shi\u00a07\u00a08,\u00a0Colin Theng\u00a09,\u00a0Azura Mohd Affandi\u00a010,\u00a0Chul Hwan Bang\u00a011,\u00a0Maria Lorna Frez\u00a012,\u00a0Huang Yu Huei\u00a013\u00a014,\u00a0Doanh Le Huu\u00a015,\u00a0Tae-Gyun Kim\u00a016,\u00a0Akimichi Morita\u00a017,\u00a0Hazel H Oon\u00a018\u00a019,\u00a0Pablo Fern\u00e1ndez-Pe\u00f1as\u00a020\u00a021,\u00a0Natta Rajatanavin\u00a022,\u00a0Suganthy Robinson\u00a010,\u00a0Latha Selvarajah\u00a023,\u00a0Tsen-Fang Tsai\u00a024 J Dermatol.\u00a02024 Dec;51(12):1579-1595.\u00a0doi: 10.1111\/1346-8138.17471.\u00a0Epub 2024 Oct 10. Generalized pustular psoriasis (GPP) is a rare, chronic, heterogeneous, and potentially life-threatening disease characterized by primary, sterile, and macroscopically […]<\/p>\n","protected":false},"template":"","scientific_tags":[815,394,348,897,405,72,375],"class_list":["post-11074","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-algorithm","scientific_tags-consensus","scientific_tags-generalized-pustular-psoriasis","scientific_tags-management","scientific_tags-pediatric","scientific_tags-pregnancy","scientific_tags-severity"],"acf":{"sc_authors":"https:\/\/pubmed.ncbi.nlm.nih.gov\/39390737\/<\/a>\r\n\r\nhttps:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/1346-8138.17471<\/a>"},"yoast_head":"\nAsia-Pacific consensus recommendations on the management of generalized pustular psoriasis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Asia-Pacific consensus recommendations on the management of generalized pustular psoriasis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Siew Eng Choon\u00a01,\u00a0Peter Anthony Foley\u00a02\u00a03,\u00a0Pravit Asawanonda\u00a04,\u00a0Hideki Fujita\u00a05,\u00a0Seong-Jin Jo\u00a06,\u00a0Yu-Ling Shi\u00a07\u00a08,\u00a0Colin Theng\u00a09,\u00a0Azura Mohd Affandi\u00a010,\u00a0Chul Hwan Bang\u00a011,\u00a0Maria Lorna Frez\u00a012,\u00a0Huang Yu Huei\u00a013\u00a014,\u00a0Doanh Le Huu\u00a015,\u00a0Tae-Gyun Kim\u00a016,\u00a0Akimichi Morita\u00a017,\u00a0Hazel H Oon\u00a018\u00a019,\u00a0Pablo Fern\u00e1ndez-Pe\u00f1as\u00a020\u00a021,\u00a0Natta Rajatanavin\u00a022,\u00a0Suganthy Robinson\u00a010,\u00a0Latha Selvarajah\u00a023,\u00a0Tsen-Fang Tsai\u00a024 J Dermatol.\u00a02024 Dec;51(12):1579-1595.\u00a0doi: 10.1111\/1346-8138.17471.\u00a0Epub 2024 Oct 10. Generalized pustular psoriasis (GPP) is a rare, chronic, heterogeneous, and potentially life-threatening disease characterized by primary, sterile, and macroscopically […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-08T11:56:46+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis\/\",\"name\":\"Asia-Pacific consensus recommendations on the management of generalized pustular psoriasis - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-10-10T11:51:00+00:00\",\"dateModified\":\"2025-08-08T11:56:46+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Asia-Pacific consensus recommendations on the management of generalized pustular psoriasis - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis\/","og_locale":"de_DE","og_type":"article","og_title":"Asia-Pacific consensus recommendations on the management of generalized pustular psoriasis - Adacyte","og_description":"Siew Eng Choon\u00a01,\u00a0Peter Anthony Foley\u00a02\u00a03,\u00a0Pravit Asawanonda\u00a04,\u00a0Hideki Fujita\u00a05,\u00a0Seong-Jin Jo\u00a06,\u00a0Yu-Ling Shi\u00a07\u00a08,\u00a0Colin Theng\u00a09,\u00a0Azura Mohd Affandi\u00a010,\u00a0Chul Hwan Bang\u00a011,\u00a0Maria Lorna Frez\u00a012,\u00a0Huang Yu Huei\u00a013\u00a014,\u00a0Doanh Le Huu\u00a015,\u00a0Tae-Gyun Kim\u00a016,\u00a0Akimichi Morita\u00a017,\u00a0Hazel H Oon\u00a018\u00a019,\u00a0Pablo Fern\u00e1ndez-Pe\u00f1as\u00a020\u00a021,\u00a0Natta Rajatanavin\u00a022,\u00a0Suganthy Robinson\u00a010,\u00a0Latha Selvarajah\u00a023,\u00a0Tsen-Fang Tsai\u00a024 J Dermatol.\u00a02024 Dec;51(12):1579-1595.\u00a0doi: 10.1111\/1346-8138.17471.\u00a0Epub 2024 Oct 10. Generalized pustular psoriasis (GPP) is a rare, chronic, heterogeneous, and potentially life-threatening disease characterized by primary, sterile, and macroscopically […]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis\/","og_site_name":"Adacyte","article_modified_time":"2025-08-08T11:56:46+00:00","twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"2\u00a0Minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis\/","name":"Asia-Pacific consensus recommendations on the management of generalized pustular psoriasis - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2024-10-10T11:51:00+00:00","dateModified":"2025-08-08T11:56:46+00:00","inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/asia-pacific-consensus-recommendations-on-the-management-of-generalized-pustular-psoriasis\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner\/11074","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/media?parent=11074"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific_tags?post=11074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}