{"id":11069,"date":"2024-05-07T13:23:00","date_gmt":"2024-05-07T11:23:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=11069"},"modified":"2025-08-08T13:26:45","modified_gmt":"2025-08-08T11:26:45","slug":"generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review\/","title":{"rendered":"Generalized Pustular Psoriasis of Pregnancy Successfully Treated With Certolizumab Pegol: A Case Report and Literature Review"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Pogorelov+D&amp;cauthor_id=38846233\">Dimitrii Pogorelov<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38846233\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Tschesche+A&amp;cauthor_id=38846233\">Anne Tschesche<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38846233\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Balakirski+G&amp;cauthor_id=38846233\">Galina Balakirski<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38846233\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Hofmann+SC&amp;cauthor_id=38846233\">Silke C Hofmann<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38846233\/#full-view-affiliation-1\">1<\/a><\/sup><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Cureus.\u00a02024 May 7;16(5):e59832.\u00a0doi: 10.7759\/cureus.59832.\u00a0eCollection 2024 May.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Generalized pustular psoriasis of pregnancy (GPPP) is a rare dermatological condition that significantly affects maternal health and pregnancy outcomes. The treatment of this disease might be very challenging, as only a limited number of effective therapeutic options are available. If the use of systemic drugs is considered, they should ideally effectively control the systemic inflammation without harming the fetus. Here, we report the successful treatment of a severe case of GPPP in a 28-year-old woman using the tumor necrosis factor-alpha inhibitor (TNFi) certolizumab pegol. Additionally, we review the existing literature on the use of this class of drugs for treating GPPP. To date, there are only 11 reported cases of this severe skin condition treated with a TNFi. We also discuss the pathogenesis of GPPP and the rationale behind using TNFi for its treatment.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Dimitrii Pogorelov\u00a01,\u00a0Anne Tschesche\u00a01,\u00a0Galina Balakirski\u00a01,\u00a0Silke C Hofmann\u00a01 Cureus.\u00a02024 May 7;16(5):e59832.\u00a0doi: 10.7759\/cureus.59832.\u00a0eCollection 2024 May. Generalized pustular psoriasis of pregnancy (GPPP) is a rare dermatological condition that significantly affects maternal health and pregnancy outcomes. The treatment of this disease might be very challenging, as only a limited number of effective therapeutic options are available. If the use of [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[92,134,484,348,424,89,72,156],"class_list":["post-11069","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-anti-tnf","scientific_tags-biologics","scientific_tags-certolizumab-pegol","scientific_tags-generalized-pustular-psoriasis","scientific_tags-gma","scientific_tags-impetigo-herpetiformis","scientific_tags-pregnancy","scientific_tags-safety"],"acf":{"sc_authors":"<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38846233\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38846233\/<\/a>\r\n\r\n<a href=\"https:\/\/assets.cureus.com\/uploads\/case_report\/pdf\/245363\/20240606-1999-1ii33ve.pdf\">https:\/\/assets.cureus.com\/uploads\/case_report\/pdf\/245363\/20240606-1999-1ii33ve.pdf<\/a>"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Generalized Pustular Psoriasis of Pregnancy Successfully Treated With Certolizumab Pegol: A Case Report and Literature Review - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Generalized Pustular Psoriasis of Pregnancy Successfully Treated With Certolizumab Pegol: A Case Report and Literature Review - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Dimitrii Pogorelov\u00a01,\u00a0Anne Tschesche\u00a01,\u00a0Galina Balakirski\u00a01,\u00a0Silke C Hofmann\u00a01 Cureus.\u00a02024 May 7;16(5):e59832.\u00a0doi: 10.7759\/cureus.59832.\u00a0eCollection 2024 May. Generalized pustular psoriasis of pregnancy (GPPP) is a rare dermatological condition that significantly affects maternal health and pregnancy outcomes. The treatment of this disease might be very challenging, as only a limited number of effective therapeutic options are available. If the use of [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-08T11:26:45+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"1\u00a0Minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review\/\",\"name\":\"Generalized Pustular Psoriasis of Pregnancy Successfully Treated With Certolizumab Pegol: A Case Report and Literature Review - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-05-07T11:23:00+00:00\",\"dateModified\":\"2025-08-08T11:26:45+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Generalized Pustular Psoriasis of Pregnancy Successfully Treated With Certolizumab Pegol: A Case Report and Literature Review - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review\/","og_locale":"de_DE","og_type":"article","og_title":"Generalized Pustular Psoriasis of Pregnancy Successfully Treated With Certolizumab Pegol: A Case Report and Literature Review - Adacyte","og_description":"Dimitrii Pogorelov\u00a01,\u00a0Anne Tschesche\u00a01,\u00a0Galina Balakirski\u00a01,\u00a0Silke C Hofmann\u00a01 Cureus.\u00a02024 May 7;16(5):e59832.\u00a0doi: 10.7759\/cureus.59832.\u00a0eCollection 2024 May. Generalized pustular psoriasis of pregnancy (GPPP) is a rare dermatological condition that significantly affects maternal health and pregnancy outcomes. The treatment of this disease might be very challenging, as only a limited number of effective therapeutic options are available. If the use of [&hellip;]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review\/","og_site_name":"Adacyte","article_modified_time":"2025-08-08T11:26:45+00:00","twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"1\u00a0Minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review\/","name":"Generalized Pustular Psoriasis of Pregnancy Successfully Treated With Certolizumab Pegol: A Case Report and Literature Review - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2024-05-07T11:23:00+00:00","dateModified":"2025-08-08T11:26:45+00:00","inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/generalized-pustular-psoriasis-of-pregnancy-successfully-treated-with-certolizumab-pegol-a-case-report-and-literature-review\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner\/11069","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/media?parent=11069"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific_tags?post=11069"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}