{"id":11068,"date":"2024-11-20T13:05:00","date_gmt":"2024-11-20T12:05:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=11068"},"modified":"2025-08-08T13:19:36","modified_gmt":"2025-08-08T11:19:36","slug":"enhanced-therapeutic-efficacy-of-granulocyte-monocyte-adsorption-in-rats-with-drug-induced-colitis-insights-from-a-downsized-bead-column-and-newly-formed-b-cells","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/enhanced-therapeutic-efficacy-of-granulocyte-monocyte-adsorption-in-rats-with-drug-induced-colitis-insights-from-a-downsized-bead-column-and-newly-formed-b-cells\/","title":{"rendered":"Enhanced therapeutic efficacy of granulocyte\/monocyte adsorption in rats with drug-induced colitis: Insights from a downsized bead column and newly formed B cells"},"content":{"rendered":"
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Yujin Nishioka<\/a>\u00a01<\/a><\/sup>,\u00a0Goh Murayama<\/a>\u00a01<\/a><\/sup>,\u00a0Makio Kusaoi<\/a>\u00a01<\/a><\/sup>,\u00a0Daichi Takemasa<\/a>\u00a02<\/a><\/sup>,\u00a0Kenta Kaneda<\/a>\u00a02<\/a><\/sup>,\u00a0Taiga Kuga<\/a>\u00a01<\/a><\/sup>,\u00a0Yukitomo Hagiwara<\/a>\u00a01<\/a><\/sup>,\u00a0Takumi Saito<\/a>\u00a01<\/a><\/sup>,\u00a0Yu Yamaji<\/a>\u00a01<\/a><\/sup>,\u00a0Yoshifumi Suzuki<\/a>\u00a03<\/a><\/sup>,\u00a0Tetsutaro Nagaoka<\/a>\u00a03<\/a><\/sup>,\u00a0Ken Yamaji<\/a>\u00a01<\/a><\/sup>,\u00a0Naoto Tamura<\/a>\u00a01<\/a><\/sup><\/p>\n<\/div>\n\n

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Ther Apher Dial.\u00a02024 Nov 20.\u00a0doi: 10.1111\/1744-9987.14234.\u00a0Online ahead of print.<\/p>\n<\/div>\n\n

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Introduction: <\/strong>Granulocyte\/monocyte adsorption therapy can manage mild-to-moderate inflammatory bowel disease by removing activated granulocytes and monocytes. We evaluated granulocyte\/monocyte adsorption using new columns with reduced bead size and theoretically enhanced adsorption.<\/p>\n<\/div>\n\n

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Methods: <\/strong>We assessed granulocyte\/monocyte adsorption in rats with colitis by analyzing cell changes and cytokine production.<\/p>\n<\/div>\n\n

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Results: <\/strong>Granulocyte\/monocyte adsorption with the new columns improved histology in rats with colitis. Contrary to expectations, the adsorption rate of granulocytes\/monocytes into the blood did not show a significant improvement. However, flow cytometry showed increased B cells in peripheral blood mononuclear cells and newly formed B cells in the bone marrow, which produced more interleukin-10 than peripheral blood B cells. Newly formed B cells adoptively transferred into colitis rats accumulated at the inflammation site and tended to inhibit intestinal shortening.<\/p>\n<\/div>\n\n

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Conclusions: <\/strong>Newly formed B cells with strong interleukin-10 production may alleviate inflammation. The new columns suggest potential for controlling colitis.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Yujin Nishioka\u00a01,\u00a0Goh Murayama\u00a01,\u00a0Makio Kusaoi\u00a01,\u00a0Daichi Takemasa\u00a02,\u00a0Kenta Kaneda\u00a02,\u00a0Taiga Kuga\u00a01,\u00a0Yukitomo Hagiwara\u00a01,\u00a0Takumi Saito\u00a01,\u00a0Yu Yamaji\u00a01,\u00a0Yoshifumi Suzuki\u00a03,\u00a0Tetsutaro Nagaoka\u00a03,\u00a0Ken Yamaji\u00a01,\u00a0Naoto Tamura\u00a01 Ther Apher Dial.\u00a02024 Nov 20.\u00a0doi: 10.1111\/1744-9987.14234.\u00a0Online ahead of print. Introduction: Granulocyte\/monocyte adsorption therapy can manage mild-to-moderate inflammatory bowel disease by removing activated granulocytes and monocytes. We evaluated granulocyte\/monocyte adsorption using new columns with reduced bead size and theoretically enhanced adsorption. Methods: We assessed […]<\/p>\n","protected":false},"template":"","scientific_tags":[890,424,426,201,210,173],"class_list":["post-11068","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-b-cells","scientific_tags-gma","scientific_tags-ibd","scientific_tags-il-10","scientific_tags-infiltration","scientific_tags-moa"],"acf":[],"yoast_head":"\nEnhanced therapeutic efficacy of granulocyte\/monocyte adsorption in rats with drug-induced colitis: Insights from a downsized bead column and newly formed B cells - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/enhanced-therapeutic-efficacy-of-granulocyte-monocyte-adsorption-in-rats-with-drug-induced-colitis-insights-from-a-downsized-bead-column-and-newly-formed-b-cells\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Enhanced therapeutic efficacy of granulocyte\/monocyte adsorption in rats with drug-induced colitis: Insights from a downsized bead column and newly formed B cells - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Yujin Nishioka\u00a01,\u00a0Goh Murayama\u00a01,\u00a0Makio Kusaoi\u00a01,\u00a0Daichi Takemasa\u00a02,\u00a0Kenta Kaneda\u00a02,\u00a0Taiga Kuga\u00a01,\u00a0Yukitomo Hagiwara\u00a01,\u00a0Takumi Saito\u00a01,\u00a0Yu Yamaji\u00a01,\u00a0Yoshifumi Suzuki\u00a03,\u00a0Tetsutaro Nagaoka\u00a03,\u00a0Ken Yamaji\u00a01,\u00a0Naoto Tamura\u00a01 Ther Apher Dial.\u00a02024 Nov 20.\u00a0doi: 10.1111\/1744-9987.14234.\u00a0Online ahead of print. 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