{"id":11054,"date":"2025-08-01T10:57:12","date_gmt":"2025-08-01T08:57:12","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=11054"},"modified":"2025-08-08T11:01:37","modified_gmt":"2025-08-08T09:01:37","slug":"effectiveness-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-ulcerative-colitis-and-5-aminosalicylate-intolerance","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/effectiveness-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-ulcerative-colitis-and-5-aminosalicylate-intolerance\/","title":{"rendered":"Effectiveness of granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis and 5-aminosalicylate intolerance"},"content":{"rendered":"
\n

Masaki Kato<\/a>\u00a01<\/a><\/sup>,\u00a0Masaki Yamashita<\/a>\u00a01<\/a><\/sup>,\u00a0Shigeki Kojima<\/a>\u00a02<\/a><\/sup>,\u00a0Mitsuto Tsukui<\/a>\u00a01<\/a><\/sup>,\u00a0Yoshihiko Iijima<\/a>\u00a01<\/a><\/sup>,\u00a0Kenichi Araki<\/a>\u00a01<\/a><\/sup>,\u00a0Jun Ishida<\/a>\u00a01<\/a><\/sup>,\u00a0Takumi Komatsu<\/a>\u00a01<\/a><\/sup>,\u00a0Yusuke Nakamoto<\/a>\u00a01<\/a><\/sup>,\u00a0Akiyo Kawashima<\/a>\u00a01<\/a><\/sup>,\u00a0Maki Konno<\/a>\u00a01<\/a><\/sup>,\u00a0Hirofumi Kiyokawa<\/a>\u00a01<\/a><\/sup>,\u00a0Yoshinori Sato<\/a>\u00a01<\/a><\/sup>,\u00a0Tsutomu Sakurada<\/a>\u00a02<\/a><\/sup>,\u00a0Tadateru Maehata<\/a>\u00a01<\/a><\/sup>,\u00a0Hiroshi Yasuda<\/a>\u00a01<\/a><\/sup>,\u00a0Keisuke Tateishi<\/a>\u00a01<\/a><\/sup><\/p>\n<\/div>\n\n

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Medicine (Baltimore).\u00a02025 Aug 1;104(31):e43389.\u00a0doi: 10.1097\/MD.0000000000043389.<\/p>\n<\/div>\n\n

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5-Aminosalicylate (5-ASA) intolerance complicates ulcerative colitis (UC) management, often necessitating alternative treatment approaches. Granulocyte and monocyte adsorptive apheresis (GMA) has been recognized as a safe treatment option for patients with UC who are refractory or intolerant to conventional drugs, including steroids; however, its effectiveness and safety in patients with 5-ASA intolerance remain unclear. This study aimed to investigate the effectiveness and safety of GMA in patients with UC and 5-ASA intolerance. We conducted a retrospective observational study to evaluate the effectiveness and safety of GMA in patients with UC and 5-ASA intolerance. Eighty-five patients with UC who underwent GMA were assessed, including 21 with 5-ASA intolerance and 64 with 5-ASA tolerance. This study compared the patient characteristics, treatment outcomes, concomitant drugs, and adverse events between the 2 groups. The remission rate was 28.6% (6\/21) in the 5-ASA-intolerant group and 31.3% (20\/64) in the 5-ASA-tolerant group, with no significant difference between the groups (P = .967). Both groups showed significant reductions in the dose of oral prednisolone and Lichtiger clinical activity index scores following the GMA. Our study suggests that GMA is equally effective and safe in 5-ASA-intolerant and 5-ASA-tolerant patients, offering an alternative treatment option in this challenging clinical scenario.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Masaki Kato\u00a01,\u00a0Masaki Yamashita\u00a01,\u00a0Shigeki Kojima\u00a02,\u00a0Mitsuto Tsukui\u00a01,\u00a0Yoshihiko Iijima\u00a01,\u00a0Kenichi Araki\u00a01,\u00a0Jun Ishida\u00a01,\u00a0Takumi Komatsu\u00a01,\u00a0Yusuke Nakamoto\u00a01,\u00a0Akiyo Kawashima\u00a01,\u00a0Maki Konno\u00a01,\u00a0Hirofumi Kiyokawa\u00a01,\u00a0Yoshinori Sato\u00a01,\u00a0Tsutomu Sakurada\u00a02,\u00a0Tadateru Maehata\u00a01,\u00a0Hiroshi Yasuda\u00a01,\u00a0Keisuke Tateishi\u00a01 Medicine (Baltimore).\u00a02025 Aug 1;104(31):e43389.\u00a0doi: 10.1097\/MD.0000000000043389. 5-Aminosalicylate (5-ASA) intolerance complicates ulcerative colitis (UC) management, often necessitating alternative treatment approaches. Granulocyte and monocyte adsorptive apheresis (GMA) has been recognized as a safe treatment option for patients with UC who […]<\/p>\n","protected":false},"template":"","scientific_tags":[721,446,424,827,269,48,156,354,271,306],"class_list":["post-11054","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-5-asa","scientific_tags-effectiveness","scientific_tags-gma","scientific_tags-intolerance","scientific_tags-observational","scientific_tags-retrospective","scientific_tags-safety","scientific_tags-steroid-sparing","scientific_tags-study","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"\nEffectiveness of granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis and 5-aminosalicylate intolerance - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effectiveness-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-ulcerative-colitis-and-5-aminosalicylate-intolerance\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effectiveness of granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis and 5-aminosalicylate intolerance - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Masaki Kato\u00a01,\u00a0Masaki Yamashita\u00a01,\u00a0Shigeki Kojima\u00a02,\u00a0Mitsuto Tsukui\u00a01,\u00a0Yoshihiko Iijima\u00a01,\u00a0Kenichi Araki\u00a01,\u00a0Jun Ishida\u00a01,\u00a0Takumi Komatsu\u00a01,\u00a0Yusuke Nakamoto\u00a01,\u00a0Akiyo Kawashima\u00a01,\u00a0Maki Konno\u00a01,\u00a0Hirofumi Kiyokawa\u00a01,\u00a0Yoshinori Sato\u00a01,\u00a0Tsutomu Sakurada\u00a02,\u00a0Tadateru Maehata\u00a01,\u00a0Hiroshi Yasuda\u00a01,\u00a0Keisuke Tateishi\u00a01 Medicine (Baltimore).\u00a02025 Aug 1;104(31):e43389.\u00a0doi: 10.1097\/MD.0000000000043389. 5-Aminosalicylate (5-ASA) intolerance complicates ulcerative colitis (UC) management, often necessitating alternative treatment approaches. Granulocyte and monocyte adsorptive apheresis (GMA) has been recognized as a safe treatment option for patients with UC who […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effectiveness-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-ulcerative-colitis-and-5-aminosalicylate-intolerance\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-08T09:01:37+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effectiveness-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-ulcerative-colitis-and-5-aminosalicylate-intolerance\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effectiveness-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-ulcerative-colitis-and-5-aminosalicylate-intolerance\/\",\"name\":\"Effectiveness of granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis and 5-aminosalicylate intolerance - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2025-08-01T08:57:12+00:00\",\"dateModified\":\"2025-08-08T09:01:37+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effectiveness-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-ulcerative-colitis-and-5-aminosalicylate-intolerance\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Effectiveness of granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis and 5-aminosalicylate intolerance - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/effectiveness-of-granulocyte-and-monocyte-adsorptive-apheresis-in-patients-with-ulcerative-colitis-and-5-aminosalicylate-intolerance\/","og_locale":"de_DE","og_type":"article","og_title":"Effectiveness of granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis and 5-aminosalicylate intolerance - Adacyte","og_description":"Masaki Kato\u00a01,\u00a0Masaki Yamashita\u00a01,\u00a0Shigeki Kojima\u00a02,\u00a0Mitsuto Tsukui\u00a01,\u00a0Yoshihiko Iijima\u00a01,\u00a0Kenichi Araki\u00a01,\u00a0Jun Ishida\u00a01,\u00a0Takumi Komatsu\u00a01,\u00a0Yusuke Nakamoto\u00a01,\u00a0Akiyo Kawashima\u00a01,\u00a0Maki Konno\u00a01,\u00a0Hirofumi Kiyokawa\u00a01,\u00a0Yoshinori Sato\u00a01,\u00a0Tsutomu Sakurada\u00a02,\u00a0Tadateru Maehata\u00a01,\u00a0Hiroshi Yasuda\u00a01,\u00a0Keisuke Tateishi\u00a01 Medicine (Baltimore).\u00a02025 Aug 1;104(31):e43389.\u00a0doi: 10.1097\/MD.0000000000043389. 5-Aminosalicylate (5-ASA) intolerance complicates ulcerative colitis (UC) management, often necessitating alternative treatment approaches. 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