{"id":11050,"date":"2025-01-08T10:35:00","date_gmt":"2025-01-08T09:35:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=11050"},"modified":"2025-08-08T10:55:37","modified_gmt":"2025-08-08T08:55:37","slug":"p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor\/","title":{"rendered":"P0684 Real world experience with granulocyte and monocyte adsorptive apheresis (ADACOLUMN\u00ae) in patients with refractory inflammatory bowel disease: a retrospective observational multicenter cohort study\u00a0"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"javascript:;\">M Hup\u00e9<\/a>\u00a0,\u00a0<a href=\"javascript:;\">G Bouguen<\/a>\u00a0,\u00a0<a href=\"javascript:;\">A Buisson<\/a>\u00a0,\u00a0<a href=\"javascript:;\">C Landman<\/a>\u00a0,\u00a0<a href=\"javascript:;\">M Uzzan<\/a>\u00a0,\u00a0<a href=\"javascript:;\">S Nancey<\/a>\u00a0,\u00a0<a href=\"javascript:;\">C Guillaume<\/a>\u00a0,\u00a0<a href=\"javascript:;\">G Cyrielle<\/a>\u00a0,\u00a0<a href=\"javascript:;\">M Charkaoui<\/a>\u00a0,\u00a0<a href=\"javascript:;\">M Serrero<\/a>\u00a0,\u00a0<a href=\"javascript:;\">A Wampach<\/a>\u00a0,\u00a0<a href=\"javascript:;\">M Collins<\/a>\u00a0,\u00a0<a href=\"javascript:;\">R Altwegg<\/a>\u00a0,\u00a0<a href=\"javascript:;\">F Cholet<\/a>\u00a0,\u00a0<a href=\"javascript:;\">A Amiot<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><em>Journal of Crohn&#8217;s and Colitis<\/em>, Volume 19, Issue Supplement_1, January 2025, Page i1338,\u00a0<a href=\"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjae190.0858\">https:\/\/doi.org\/10.1093\/ecco-jcc\/jjae190.0858<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Background: <\/strong>Granulocyte and monocyte adsorptive apheresis (GMA) with ADACOLUMN\u00ae (JIMRO Takasaki Japan) is an effective and safe therapeutic option for patients with mild to moderate inflammatory bowel disease (IBD) refractory to pharmacological therapy, especially ulcerative colitis (UC). The aim of this study was to report effectiveness of GMA in patients with IBD.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Methods<\/strong>: All consecutive active, non-operated UC patients and Crohn\u2019s disease (CD) patients treated with GMA in 15 French tertiary-care centres from 2007 to september 2024 were assessed. Patients received 4 to 8 weekly sessions of GMA alone or in combination with previously failing advanced therapy. Patients were assessed for effectiveness at week 14 and at week 54 for those continuing GMA as maintenance therapy and at every visit for safety. Clinical remission, steroid-free clinical remission, clinical response, colectomy as well as safety were ascertained.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Results:<\/strong> One hundred and twenty-nine patients with IBD (75 males, median age: 40.9 IQR[29.3-58.1] years, 102 with UC, IBD duration: 7.0 [2.9-13.1] years) were included. One hundred patients (77.5%) were previously treated with immunosuppressants and 97 (72.2%) with at least one anti-TNF. In patients with UC, baseline median total Mayo score was 7 [6-12] and mean CRP level was 23.3 \u00b1 86.0 mg\/L. In patients with CD, baseline median Harvey-Bradshaw index was 9 [7.25-10.75] and mean CRP level was 21.9 \u00b1 27.3 mg\/L. In patients with UC, week 14 clinical remission, steroid-free clinical remission and response rates were 33.3%, 27.5% and 52.0%, respectively. In patients with CD, week 14 clinical remission, steroid-free clinical remission and response rates were 33.3%, 29.6% and 66.7%, respectively. At week 14, nine patients with UC and 3 patients with CD required emergent surgery. At week 14, adverse events were reported in 26 (20.2%) and were mainly related to flare of IBD in 16 (12.4%). Other adverse events which were never classified as serious included headache in 3, arthromyalgia in 3 and abdominal pain, diarrhea, grade-1 increase in liver enzymes and mild hypotension in one. At week 54, 48 patients were still treated with maintenance GMA therapy including 13 with CD and 35 with UC. At week 54, steroid-free clinical remission rates were 38.5% (5\/13) in patients with CD and 60% (21\/35) in patients with UC.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Conclusion<\/strong>: In this real world cohort of patients with refractory IBD, GMA induced steroid-free clinical remission in one third of patients with CD and UC at W14. In patients continuing GMA maintenance therapy, steroid-free clinical remission was observed in one third of patients with CD and two thirds of patients with UC. Safety profile was favourable mostly related to relapse of IBD.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>M Hup\u00e9\u00a0,\u00a0G Bouguen\u00a0,\u00a0A Buisson\u00a0,\u00a0C Landman\u00a0,\u00a0M Uzzan\u00a0,\u00a0S Nancey\u00a0,\u00a0C Guillaume\u00a0,\u00a0G Cyrielle\u00a0,\u00a0M Charkaoui\u00a0,\u00a0M Serrero\u00a0,\u00a0A Wampach\u00a0,\u00a0M Collins\u00a0,\u00a0R Altwegg\u00a0,\u00a0F Cholet\u00a0,\u00a0A Amiot Journal of Crohn&#8217;s and Colitis, Volume 19, Issue Supplement_1, January 2025, Page i1338,\u00a0https:\/\/doi.org\/10.1093\/ecco-jcc\/jjae190.0858 Background: Granulocyte and monocyte adsorptive apheresis (GMA) with ADACOLUMN\u00ae (JIMRO Takasaki Japan) is an effective and safe therapeutic option for patients with mild to moderate inflammatory [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[157,424,426,100,269,461,48,850,156,309,271],"class_list":["post-11050","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-efficacy","scientific_tags-gma","scientific_tags-ibd","scientific_tags-multicenter","scientific_tags-observational","scientific_tags-refractory","scientific_tags-retrospective","scientific_tags-rwe","scientific_tags-safety","scientific_tags-steroid-free","scientific_tags-study"],"acf":{"sc_authors":"<a href=\"https:\/\/academic.oup.com\/ecco-jcc\/article\/19\/Supplement_1\/i1338\/7967807#google_vignette\">https:\/\/academic.oup.com\/ecco-jcc\/article\/19\/Supplement_1\/i1338\/7967807#google_vignette<\/a>\r\n\r\n&nbsp;"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>P0684 Real world experience with granulocyte and monocyte adsorptive apheresis (ADACOLUMN\u00ae) in patients with refractory inflammatory bowel disease: a retrospective observational multicenter cohort study\u00a0 - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"P0684 Real world experience with granulocyte and monocyte adsorptive apheresis (ADACOLUMN\u00ae) in patients with refractory inflammatory bowel disease: a retrospective observational multicenter cohort study\u00a0 - Adacyte\" \/>\n<meta property=\"og:description\" content=\"M Hup\u00e9\u00a0,\u00a0G Bouguen\u00a0,\u00a0A Buisson\u00a0,\u00a0C Landman\u00a0,\u00a0M Uzzan\u00a0,\u00a0S Nancey\u00a0,\u00a0C Guillaume\u00a0,\u00a0G Cyrielle\u00a0,\u00a0M Charkaoui\u00a0,\u00a0M Serrero\u00a0,\u00a0A Wampach\u00a0,\u00a0M Collins\u00a0,\u00a0R Altwegg\u00a0,\u00a0F Cholet\u00a0,\u00a0A Amiot Journal of Crohn&#8217;s and Colitis, Volume 19, Issue Supplement_1, January 2025, Page i1338,\u00a0https:\/\/doi.org\/10.1093\/ecco-jcc\/jjae190.0858 Background: Granulocyte and monocyte adsorptive apheresis (GMA) with ADACOLUMN\u00ae (JIMRO Takasaki Japan) is an effective and safe therapeutic option for patients with mild to moderate inflammatory [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-08T08:55:37+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"3\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor\/\",\"name\":\"P0684 Real world experience with granulocyte and monocyte adsorptive apheresis (ADACOLUMN\u00ae) in patients with refractory inflammatory bowel disease: a retrospective observational multicenter cohort study\u00a0 - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2025-01-08T09:35:00+00:00\",\"dateModified\":\"2025-08-08T08:55:37+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"P0684 Real world experience with granulocyte and monocyte adsorptive apheresis (ADACOLUMN\u00ae) in patients with refractory inflammatory bowel disease: a retrospective observational multicenter cohort study\u00a0 - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor\/","og_locale":"de_DE","og_type":"article","og_title":"P0684 Real world experience with granulocyte and monocyte adsorptive apheresis (ADACOLUMN\u00ae) in patients with refractory inflammatory bowel disease: a retrospective observational multicenter cohort study\u00a0 - Adacyte","og_description":"M Hup\u00e9\u00a0,\u00a0G Bouguen\u00a0,\u00a0A Buisson\u00a0,\u00a0C Landman\u00a0,\u00a0M Uzzan\u00a0,\u00a0S Nancey\u00a0,\u00a0C Guillaume\u00a0,\u00a0G Cyrielle\u00a0,\u00a0M Charkaoui\u00a0,\u00a0M Serrero\u00a0,\u00a0A Wampach\u00a0,\u00a0M Collins\u00a0,\u00a0R Altwegg\u00a0,\u00a0F Cholet\u00a0,\u00a0A Amiot Journal of Crohn&#8217;s and Colitis, Volume 19, Issue Supplement_1, January 2025, Page i1338,\u00a0https:\/\/doi.org\/10.1093\/ecco-jcc\/jjae190.0858 Background: Granulocyte and monocyte adsorptive apheresis (GMA) with ADACOLUMN\u00ae (JIMRO Takasaki Japan) is an effective and safe therapeutic option for patients with mild to moderate inflammatory [&hellip;]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor\/","og_site_name":"Adacyte","article_modified_time":"2025-08-08T08:55:37+00:00","twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"3\u00a0Minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor\/","name":"P0684 Real world experience with granulocyte and monocyte adsorptive apheresis (ADACOLUMN\u00ae) in patients with refractory inflammatory bowel disease: a retrospective observational multicenter cohort study\u00a0 - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2025-01-08T09:35:00+00:00","dateModified":"2025-08-08T08:55:37+00:00","inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/p0684-real-world-experience-with-granulocyte-and-monocyte-adsorptive-apheresis-adacolumn-in-patients-with-refractory-inflammatory-bowel-disease-a-retrospective-observational-multicenter-cohor\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner\/11050","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/media?parent=11050"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/de\/wp-json\/wp\/v2\/scientific_tags?post=11050"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}