{"id":11018,"date":"2024-01-07T15:52:00","date_gmt":"2024-01-07T14:52:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=11018"},"modified":"2025-08-07T15:57:28","modified_gmt":"2025-08-07T13:57:28","slug":"p426-hematological-composite-scores-in-patients-with-inflammatory-bowel-disease","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/de\/professional\/scientific-corner\/p426-hematological-composite-scores-in-patients-with-inflammatory-bowel-disease\/","title":{"rendered":"P426 Hematological Composite Scores in Patients with Inflammatory Bowel Disease"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"javascript:;\">A Morant-Dom\u00ednguez<\/a>\u00a0,\u00a0<a href=\"javascript:;\">B Vera-Santana<\/a>\u00a0,\u00a0<a href=\"javascript:;\">A Hern\u00e1ndez-Camba<\/a>\u00a0,\u00a0<a href=\"javascript:;\">L Ramos<\/a>\u00a0,\u00a0<a href=\"javascript:;\">I Alonso-Abreu<\/a>\u00a0,\u00a0<a href=\"javascript:;\">N Hern\u00e1ndez \u00c1lvarez-Buylla<\/a>\u00a0,\u00a0<a href=\"javascript:;\">M Vela<\/a>\u00a0,\u00a0<a href=\"javascript:;\">M Hern\u00e1ndez-Guerra<\/a>\u00a0,\u00a0<a href=\"javascript:;\">A Laura<\/a>\u00a0,\u00a0<a href=\"javascript:;\">I Ferraz-Amaro<\/a>\u00a0,\u00a0<a href=\"javascript:;\">M Carrillo Palau<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Journal of Crohn&#8217;s and Colitis, Volume 18, Issue Supplement_1, January 2024, Page i870,\u00a0 <a href=\"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad212.0556\">https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad212.0556<\/a><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Background<\/strong>: Ulcerative colitis (CU) and Crohn\u2019s disease (CD) are described as inflammatory bowel diseases (IBD). Emerging as potential blood-based inflammatory biomarkers in various chronic diseases are the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SIRI, calculated as neutrophils \u00d7 monocytes\/lymphocytes). In this work we aim to analyze if these hematological composite scores differ between IBD patients and healthy controls, and whether they are related to disease activity.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Methods<\/strong>: A total of 197 IBD patients, 130 with CD and 67 with CU, and 208 age- and sex-matched healthy controls were recruited. NLR, MLR, PLR, and SIRI were calculated. Multivariable linear regression analysis was performed to study whether these scores differ between patients and controls and how they related to IBD activity scores.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Results<\/strong>: After multivariable analysis adjustment, NLR and PLR, but not SIRI and MLR, were significantly higher in IBD patients compared to controls (table 1). C-reactive protein and SIRI and NLR correlated in patients with IBD. Nevertheless, fecal calprotectin was not related to none of these blood scores. Besides, disease activity parameters were not associated with any of the composite blood-based scores in both patients with CD and CU.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Conclusion<\/strong>: NLR and PLR, independently, are heightened in IBD patients in contrast to controls. However, SIRI and MLR do not share this distinction. Surprisingly, none of the four hematological scores displayed correlations with disease activity in either CD or UC patients.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>A Morant-Dom\u00ednguez\u00a0,\u00a0B Vera-Santana\u00a0,\u00a0A Hern\u00e1ndez-Camba\u00a0,\u00a0L Ramos\u00a0,\u00a0I Alonso-Abreu\u00a0,\u00a0N Hern\u00e1ndez \u00c1lvarez-Buylla\u00a0,\u00a0M Vela\u00a0,\u00a0M Hern\u00e1ndez-Guerra\u00a0,\u00a0A Laura\u00a0,\u00a0I Ferraz-Amaro\u00a0,\u00a0M Carrillo Palau Journal of Crohn&#8217;s and Colitis, Volume 18, Issue Supplement_1, January 2024, Page i870,\u00a0 https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad212.0556 Background: Ulcerative colitis (CU) and Crohn\u2019s disease (CD) are described as inflammatory bowel diseases (IBD). Emerging as potential blood-based inflammatory biomarkers in various chronic diseases are the [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[159,855,654,426,853,655,852,707,854,306],"class_list":["post-11018","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-crohns-disease","scientific_tags-disease-activity","scientific_tags-fecal-calprotectin","scientific_tags-ibd","scientific_tags-mlr","scientific_tags-nlr","scientific_tags-pcr","scientific_tags-plr","scientific_tags-siri","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":"<a href=\"https:\/\/academic.oup.com\/ecco-jcc\/article\/18\/Supplement_1\/i870\/7586468\">P426 Hematological Composite Scores in Patients with Inflammatory Bowel Disease | Journal of Crohn's and Colitis | Oxford Academic<\/a>"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>P426 Hematological Composite Scores in Patients with Inflammatory Bowel Disease - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p426-hematological-composite-scores-in-patients-with-inflammatory-bowel-disease\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"P426 Hematological Composite Scores in Patients with Inflammatory Bowel Disease - Adacyte\" \/>\n<meta property=\"og:description\" content=\"A Morant-Dom\u00ednguez\u00a0,\u00a0B Vera-Santana\u00a0,\u00a0A Hern\u00e1ndez-Camba\u00a0,\u00a0L Ramos\u00a0,\u00a0I Alonso-Abreu\u00a0,\u00a0N Hern\u00e1ndez \u00c1lvarez-Buylla\u00a0,\u00a0M Vela\u00a0,\u00a0M Hern\u00e1ndez-Guerra\u00a0,\u00a0A Laura\u00a0,\u00a0I Ferraz-Amaro\u00a0,\u00a0M Carrillo Palau Journal of Crohn&#8217;s and Colitis, Volume 18, Issue Supplement_1, January 2024, Page i870,\u00a0 https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad212.0556 Background: Ulcerative colitis (CU) and Crohn\u2019s disease (CD) are described as inflammatory bowel diseases (IBD). Emerging as potential blood-based inflammatory biomarkers in various chronic diseases are the [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p426-hematological-composite-scores-in-patients-with-inflammatory-bowel-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-07T13:57:28+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p426-hematological-composite-scores-in-patients-with-inflammatory-bowel-disease\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p426-hematological-composite-scores-in-patients-with-inflammatory-bowel-disease\/\",\"name\":\"P426 Hematological Composite Scores in Patients with Inflammatory Bowel Disease - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-01-07T14:52:00+00:00\",\"dateModified\":\"2025-08-07T13:57:28+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p426-hematological-composite-scores-in-patients-with-inflammatory-bowel-disease\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"P426 Hematological Composite Scores in Patients with Inflammatory Bowel Disease - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/p426-hematological-composite-scores-in-patients-with-inflammatory-bowel-disease\/","og_locale":"de_DE","og_type":"article","og_title":"P426 Hematological Composite Scores in Patients with Inflammatory Bowel Disease - Adacyte","og_description":"A Morant-Dom\u00ednguez\u00a0,\u00a0B Vera-Santana\u00a0,\u00a0A Hern\u00e1ndez-Camba\u00a0,\u00a0L Ramos\u00a0,\u00a0I Alonso-Abreu\u00a0,\u00a0N Hern\u00e1ndez \u00c1lvarez-Buylla\u00a0,\u00a0M Vela\u00a0,\u00a0M Hern\u00e1ndez-Guerra\u00a0,\u00a0A Laura\u00a0,\u00a0I Ferraz-Amaro\u00a0,\u00a0M Carrillo Palau Journal of Crohn&#8217;s and Colitis, Volume 18, Issue Supplement_1, January 2024, Page i870,\u00a0 https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad212.0556 Background: Ulcerative colitis (CU) and Crohn\u2019s disease (CD) are described as inflammatory bowel diseases (IBD). 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